Pluripotent stem cells: private obsession and public expectation

Pluripotent stem cells: private obsession and public expectation

In the 1960s it was shown that a rare type of tumour called a teratocarcinoma contains cells that are both pluripotent and self-renewing (Kleinsmith & Pierce, 1964). Pluripotent means the capacity of an individual cell to give rise to all other cell types of the body and the germline. This property is normally restricted to a brief window in early development. Selfrenewal is the production of i...

Induced Pluripotent Stem Cells: Challenges and Opportunities

Regenerative capacity of mammals is limited and can rarely regenerate a specific organ or tissue fully. Due to these limitations, regenerative medicine seeks efficient and safe cell sources for regeneration of damaged tissues and organs or treatment for incurable diseases. Human embryonic stem cells (HESCs) hold two important properties called self renewal and pluripotency. However, the use of ...

induced pluripotent stem cells: challenges and opportunities

regenerative capacity of mammals is limited and can rarely regenerate a specific organ or tissue fully. due to these limitations, regenerative medicine seeks efficient and safe cell sources for regeneration of damaged tissues and organs or treatment for incurable diseases. human embryonic stem cells (hescs) hold two important properties called self renewal and pluripotency. however, the use of ...

Embryonic Stem Cells/induced Pluripotent Stem Cells

Understanding the regulation of cell-cell interactions during the formation of compact myocardial structures is important for achieving true cardiac regeneration through enhancing the integration of stem cell-derived cardiomyocytes into the recipient myocardium. In this study, we found that cellular repressor of E1A-stimulated genes 1 (CREG1) is highly expressed in both embryonic and adult hear...

Human Testis–Derived Pluripotent Cells and Induced Pluripotent Stem Cells